Fátima Grossi (1).jpeg

Maria Fatima Grossi-de-Sa

Coordinator PlantStress Biotech INCT

Researcher Group Leader at Embrapa Genetic Resources and Biotechnology

E-mail: fatima.grossi@embrapa.br

Telephone: +55 (61) 99965-6736

PROFILE

Maria Fatima Grossi-de-Sa is a Researcher Group Leader at EMBRAPA Genetic Resources and Biotechnology and Professor at the Catholic University of Brasília, Brasília-DF, Brazil. She is also the Coordinator of the National Institute of Science and Technology – PlantStress Biotech INCT at EMBRAPA and Director President of the Brazilian Society of Biotechnology. She is a full member of the Brazilian Academy of Sciences and the World Academy of Science (TWAS). In 2018, she received the Commander medal of the National Order of Scientific Merit. She heads the Plant Pest Molecular Interaction Laboratory and works in a wide range of research interests with an emphasis on plant biotechnology. Her main research interest are plant pest’s molecular interactions focused on phytonematodes and insect-pests, the development of GM crop plants for tolerance/resistance to abiotic stress and biotic stresses, the understanding of the molecular RNAi mechanism on insect pests, and the development of biopharmaceuticals. She is classified as scientific researcher 1A at Brazilian National Research Council (CNPq), has coordinated several research projects at EMBRAPA, FAP-DF, CAPES, and CNPq, and currently, her research group is also funded by industry and the productive sector of agribusiness.

EDUCATION

  • B.Sc. In Biological Sciences, University of Brasilia, Brazil, 1979.

  • M.Sc.  In Molecular Biology, University of Brasilia, Brazil, 1982.

  • Ph.D. University PARIS VII, Paris, France, 1987.

CURRENT POSITION

  • Researcher Leader on Plant Biotechnology at EMBRAPA Genetic Resources and Biotechnology - Brasilia- DF, Brazil (since 1989).

  • Senior Associate Professor at Catholic University of Brasilia (UCB), Brasilia-DF, Brazil (since 2004).

  • President of Brazilian Society of Biotechnology (since 2016).

  • Director of the National Institute Science & Technology on Plant Stress Biotechnology (INCT PlantStress Biotech; since 2016).

HONOURS/AWARDS

  • Award of Excellence in recognition of Outstanding Research Performance by Embrapa (2009).

  • Award Brazil SCOPUS Awards 2010 - Elsevier/CAPES (2010).

  • Full elected member of Brazilian Academy of Sciences (Elected May 2011).

  • Full elected member of the World Academy of Sciences (Elected Nov 2014).

  • National Order of Scientific Merit - Commander Class, Ministry of Science and Technology - Presidency of the Republic (2018).

RESEARCH INTERESTS

The main research interests focusing on novel and innovative approaches to crop protection, which cover, plant-nematode and insect interactions, transgenic crops, biotic and abiotic stresses, plant genome editing, gene silencing, insect nanobiotechnology, biopesticides based on RNA interference approaches, and recombinant proteins.

RELEVANT PAPERS (LAST 7 YEARS)

PATENTS

HEMERLY, A.S.; Cavalcanti, P.F.; Gong, P.; Nelissen, H.; Inze, D.; Grossi-de-Sa, M.F.; Basso, M.F.; Morgante, C.V.; Lisei-de-Sa, M.E. Method for promoting an increase in plant biomass, productivity, and drought resistance. US 2020/0347399 A1. Deposit: May 4, 2020. Publication: November 5, 2020.

GROSSI-DE-SA, M.F.; Silva, M.C.M.; Fonseca, F.C.A.; Macedo, L.L.P.; Lourenco, I.T.; Albuquerque, E.V.S. Aparato e método de criação de larvas de insetos em laboratório. BR 1020130331120 B1. Deposit: December 20, 2013. Patent granted: November 24, 2020.

GROSSI-DE-SA, M.F.; Oliveira, G.R.; Silva, M.C.M.; Rocha, T.L.; Magalhaes, M.T.Q. Molécula de ácido nucléico isolada, construção gênica, vetor, célula transgênica, método para obtenção de uma célula e de uma planta transgênica. PI 0906128-2 B1. Deposit: July 24, 2009. Patent granted: March 17, 2020.

GROSSI-DE-SA, M.F.; Macedo, L.L.P.; Silva, M.C.M.; Almeida-Garcia, R.; Silva, L.P.; Vila, A. Pesticide. WO 2020/007450 A1. Deposit: July 7, 2018, Publication: January 9, 2020.

GROSSI-DE-SA, M.F.; Macedo, L.L.P.; Pinto, C.E.M.; Leite, A.G.B.; Silva, M.C.M.; Lourenço-Tessutti, I.T.; Morgante, C.V. Método para produzir planta resistente a inseto praga e moléculas de ácido nucleicos utilizado para obtenção de tal planta através de dsRNAs relacionados a ecdise. PI 102020004312-9. Deposit: March 3, 2020.

ROCHA, T.L.; Evaristo, R.G.S.; Grossi-de-Sa, M.F.; Silva, M.C.M.; Polez, V.L.P.; Roessner, U.; Bacic, T. Nematotoxic composition of synergistic effect, use of a nematotoxic composition of synergistic effect. US 9750247 B2, CN 105007725 B. Deposit: December 26, 2013 (US and CH). Patent granted: September 5, 2017 (US) and April 4, 2019 (CH).

MACEDO, L.L.P.; Grossi-de-Sa, M.F.; Silva, M.C.M.; Almeida-Garcia, R.; Mendes, R.A.G.; Albuquerque, E.V.S. Increasing the efficiency of supression of gene expression by means of the use of RNA molecules with a stabilized structure. BR 10201700690-4 A2, WO 2018/184083 A1. Deposit: April 4, 2017 (BR) and March 29, 2018 (US). Publication: October 30, 2018 (BR) and November 11, 2018 (US).

GROSSI-DE-SA, M.F.; Silva, M.C.M.; Del-Sarto, R.P.; Rocha, T.L. Mutantes de inibidores de alfa amilases isolados de Phaseolus vulgaris com propriedades de controlar insetos-praga, composições contendo tais mutantes e métodos de obtenção dos mesmos e de linhagens transgênicas. PI 1102841-6. Deposit: June 8, 2011. Patent granted: November 26, 2018.

GROSSI-DE-SA, M.F.; Coelho, R.R.; Firmino, A.A.P.; Macedo, L.L.P; Silva, M.C.M.; Lourenço-Tessutti, I.T. Método e composições para controle de insetos-praga em plantas por meio do silenciamento de genes da família da quintina sintase e da vitelogenina bem como alternativamente pela expressão do gene de uma toxina Cry. BR 102013032649-6 A2. Deposit: December 18, 2013. Publication: February 10, 2016.

SOUZA, D.S.L.; Silva, M.C.M.; Grossi-de-Sa, M.F.; Evaristo, R.G.S.; Rocha, T.L.; Bacic, T.; Roessner, U.; Polez, V.L.P. Composição nematotóxica de efeito sinérgico, uso de composição nematotóxica de efeito sinérgico. BR 10201203314-6 A2. Deposit: December 26, 2012. Patent granted: August 26, 2014.

MESSENBERG, P.G.; Grossi-de-Sa, M.F. Métodos para detecção e identificação de Curtobacterium flaccumfaciens pv flaccumfaciens em uma amostra biológica e método de certificação de sementes. PI 9806477-0. Deposit: June 23, 1998. Patent granted:  April 29, 2014.

GROSSI-DE-SA, M.F.; Silva, M.C.M.; Macedo, L.L.P.; Firmino, A.A.P.; Coelho, R.R.; Lourenço-Tessuti, I.T. Método e composições para controle genético de insetos-praga em plantas de algodão através do silenciamento de genes de quitina sintases. BR 102012033539-5 A2, US 10182571 B2 and WO 2014/100879 A2. Deposit: December 28, 2012 (BR), December 27, 2013 (US) and June 27, 2013 (WO).  Publication: August 18, 2015 (BR), January 22, 2019 (US) and January 3, 2014 (WO).

GROSSI-DE-SA, M.F.; Silva, M.C.M.; Gomes-Jr, J.E.; Lourenço-Tessuti, I.T.; Macedo, L.P.P.; Lucena, W.A.; Fonseca, F.C.A. Moléculas variantes sintéticas de toxinas Cry1Ia12 com propriedades de controlar insetos-praga, composições contendo tais mutantes e método de utilização dos mesmos. WO 2014-100880 A3. Deposit: 02/12/2012. Publication: July 3, 2014.

GROSSI-DE-SA, M.F.; Romano, E.; Fragoso, R.R.; Silva, M.C.M.; Ferreira, A.V.J.; (2013). Cassete de expressão para indução de resistência a múltiplas espécies de nematóides em plantas, métodos e plantas que o utilizam. WO 2014/197951 A2. Deposit: June 11, 2013. Publication: December 18, 2014.

GROSSI-DE-SA, M.F.; Firmino, A.A.P.; Silva, M.C.M.; Martins-de-Sa, D.; Coelho, R.R.; Macedo, L.L.P.; Lourenço-Tessuti, I.T. Método e composições para controle genético de insetos-praga em plantas de algodão através do silenciamento de genes de lacases. WO 2014/100878 A3. Deposit: December 27, 2013. Publication: July 3, 2014.

ALVES-FERREIRA, M.; Grossi-de-Sa, M.F.; Lambret, J.; Nardeli, S.M.; Artico, S. Compositions and method for modifying gene expression using a promoter of genes specific to plant flowers and fruit. WO 2014/000075 A2. Deposit: June 27, 2012. Publication: January 3, 2014.

GROSSI-DE-SA, M.F.; Guimaraes, L.M.; Batista, J.A.N.; Viana, A.A.B.; Fragoso, R.R.; Rocha, T.L. Composições e métodos para modificar a expressão de genes usando o promotor do gene da proteína de conjugação à ubiquitina de plantas de algodoeiro. PI 0701230-6, US 2013/0152226 A1. Deposit: February 5, 2007 (BR) and February 19, 2013 (US). Patent granted: June 26, 2018 (BR) and June 13, 2013 (US).

OLIVEIRA, G.R.; Marra, B.M.; Grossi-de-Sa, M.F. Processo de uso industrial e agronômico de ácidos graxos e/ou borra de algodão e/ou borra de soja e/ou borra de mamona e demais borras e seus componentes, como molécula (s), com efeito, nematicida e/ou nematostático e/ou de controle de nematóides. BR 102012007851 A2. Deposit: April 5, 2012. Publication: November 24, 2012.

ALVES-FERREIRA, M.; Waltenberg, F.P.C.; Romano, E.; Grossi-de-Sa, M.F. Utilização do gene homeobox de café cahb12 na produção de plantas transgênicas mais tolerantes ao déficit hídrico e estresse salino. WO 2012/061911 A9. Deposit: November 8, 2011. Publication: May 18, 2012.

CARLINI, C.R.R.S.; Ferreira, C.T.S.; Moraes, M.G.; Mulinari, F.; Silva, M.A.F.; Grossi-de-Sa, M.F.; Kurtenbach, E. Toxina praguicida, construção gênica e método de controle de pragas. PI 0403435-0 A. Deposit: April 8, 2004. Publication: August 1, 2006.

SCHERRER, K.; Grossi-de-Sa, M.F. Monoclonal antibodies against prosomal proteins (covering any p-Mab against prosomes). EP 0434670 B1. Deposit: August 29, 1986. Publication: June 11, 1997.

SCHERRER, K.; Grossi-de-Sa, M.F. Monoclonal antibodies against prosomal proteins (covering p27k and p31k p-Mabs). EP 0219368 B1. Deposit: August 29, 1986. Publication: March 11, 1992.

2022

FRAGOSO, R.R.; Arraes, F.B.M.; Lourenço-Tessutti, I.T.; Miranda, V.J.; Basso, M.F.; Ferreira, A.V.J.; Viana, A.A.B.; Lins, C.B.J.; Lins, P.C.; Moura, S.M.; Batista, J.A.N.; Silva, M.C.M.; Engler, G.; Morgante, C.V.; Lisei-de-Sa, M.E.; Vasques, R.M.; de Almeida-Engler J.; Grossi-de-Sa, M.F. (2022). Functional characterization of the pUceS8.3 promoter and its potential use for ectopic gene overexpression. Planta, v. 256, n. 4, p. 1-18. https://doi.org/10.1007/s00425-022-03980-6

MOURA, S.M.; Babilonia, K.; de Macedo, L.L.P.; Grossi-de-Sá, M.F.; Shan, L.; He, P.; Alves-Ferreira, M. (2022). The oral secretion from Cotton Boll Weevil (Anthonomus grandis) induces defense responses in cotton (Gossypium spp) and Arabidopsis thaliana. Current Plant Biology, p. 100250. https://doi.org/10.1016/j.cpb.2022.100250

REIS, M.A.; Noriega, D.D.; dos Santos Alves, G.; Coelho, R.R.; Grossi-de-Sa, M.F.; Antonino, J.D. (2022). Why is oral-induced RNAi inefficient in Diatraea saccharalis? A possible role for DsREase and other nucleases. Pesticide Biochemistry and Physiology, v. 186, p. 105166. https://doi.org/10.1016/j.pestbp.2022.105166

MENDES, R.A.G.; Basso, M.F.; Amora, D.X.; Silva, A.P.; Paes-de-Melo, B.; Togawa, R.C.; Albuquerque, E.V.S.; Lisei-de-Sa, M.E.; Macedo, L.L.P.; Lourenço-Tessutti, I.T.; Grossi-de-Sa, M.F. (2022). In planta RNAi approach targeting three M. incognita effector genes disturbed the process of infection and reduced plant susceptibility. Experimental Parasitology, v. 238, p. 108246, https://doi.org/10.1016/j.exppara.2022.108246

TÁVORA, F.T.P.K.; Diniz, F.A.S.; Rêgo-Machado M.C.; Freitas, N.C.; Arraes, F.B.M.; Andrade, C.E.; Furtado, L.L.; Osiro, K.O.; Lima de Sousa, N.; Cardoso, T.B.; Henning, L.M.M.; Molinari, P.A.O.; Feingold, S.E.; Hunter, W.B.; Grossi de Sá, M.F.; Kobayashi, A.K.; Nepomuceno, A.L.; Santiago, T.R.; Molinari, H.B.C. (2022). CRISPR/Cas- and topical RNAi-based technologies for crop management and improvement: reviewing the risk assessment and challenges towards a more sustainable agriculture. Frontiers in Bioengineering and Biotechnology, v. 10, p. 913728. https://doi.org/10.3389/fbioe.2022.913728

MOURA, S.M.; Freitas, E.O.; Ribeiro, T.P.; Paes-de-Melo, B.; Arraes, B.M.F.; Macedo, L.L.P.; Paixão, J.F.R.; Lourenço-Tessutti, I.T.; Artico, S.; Valença, D.C.; Silva, M.C.M.; Oliveira, A.C.; Alves-Ferreira, M.; Grossi-de-Sa, M.F. (2022). Discovery and functional characterization of novel cotton promoters with potential application to pest control. Plant Cell Reports, v. 41, p. 1589–1601. https://doi.org/10.1007/s00299-022-02880-z

HABIBI, P.; Shi, Y.; Fatima Grossi-de-Sa, M.; Khan I. (2022). Plants as sources of natural and recombinant antimalaria agents. Molecular Biotechnology. https://doi.org/10.1007/s12033-022-00499-9

RIBEIRO, D.G.; Mota, A.P.Z.; Santos, I.R.; Arraes, F.B.M.; Grynberg, P.; Fontes, W.; Castro, M.S.; Sousa, M.V.; Lisei-de-Sá, M.E.; Grossi-de-Sa, M.F.; Franco, O.L.; Mehta, A. (2022). NBS-LRR-WRKY genes and protease inhibitors (PIs) seem essential for cowpea resistance to root-knot nematode. Journal of Proteomics, p. 104575. https://doi.org/10.1016/j.jprot.2022.104575

 

MOREIRA, V.J.V.; Lourenço-Tessutti, I.T.; Basso, M.F.; Lisei-de-Sa, M.E.; Morgante, C.V.; Paes-de-Melo, B.; Arraes, F.B.M.; Martins-de-Sa, D.; Silva, M.C.M.; de Almeida Engler, J.; Grossi-de-Sa, M.F. (2022). Minc03328 effector gene downregulation severely affects Meloidogyne incognita parasitism in transgenic Arabidopsis thaliana. Planta, v. 255, p. 44-59. https://doi.org/10.1007/s00425-022-03823-4

 

2021

RODRIGUES-SILVA, P.L.; Amorim, G.C.; Andrade, I.E.P.C.; Cunha, V.A.; Figueiredo, L.H.M.; Grossi-de-Sa, M.F. (2021). Monitoramento tecnológico da planta cagaita (Eugenia dysenterica) e aplicações biotecnológicas potenciais. Cadernos de Prospecção, v. 14, p. 1248-1264. https://doi.org/10.9771/cp.v14i4.38459

RODRIGUES-SILVA, P.L.; Fernandes, P.B.B.; Rodrigues, M.T.; Figueiredo, L. H. M.; Grossi-de-Sa, M.F. (2021). Tendências quanto ao conhecimento e às aplicações biotecnológicas do Psidium guineense evidenciadas pelo monitoramento tecnológico. Cadernos de Ciência & Tecnologia, v. 38, p. e26704. https://doi.org/10.35977/0104-1096.cct2021.v38.26704

MENDES, R.A.G.; Basso, M.F.; Paes-de-Melo, B.; Ribeiro, T.P.; Lima, R.N.; Araujo, J.F.; Grossi-de-Sa, M.; Mattos, V.S.; Togawa, R.C.; Albuquerque, E.V.S.; Lisei-de-Sa, M.E.; Silva, M.C.M.; Macedo, L.L.P.; Fragoso, R.R.; Fernandez, D.; Vignols, F.; Grossi-de-Sa, M.F. (2021). The Mi-EFF1/Minc17998 effector interacts with the soybean GmHub6 protein to promote host plant parasitism by Meloidogyne incognita. Physiological and Molecular Plant Pathology, v. 114, p. 101630. https://doi.org/10.1016/j.pmpp.2021.101630

CABRAL, D.; Forero Ballesteros, H.; de Melo, B.P.; Lourenço-Tessutti, I.T.; Smões de Siqueira, K.M.; Obicci, L.; Grossi-de-Sa, M.F.; Hemerly, A.S.; de Almeida Engler, J. (2021). The armadillo BTB protein ABAP1 is a crucial player in DNA replication and transcription of nematode-induced galls. Frontiers in Plant Science, v. 12, p. 636663. https://doi.org/10.3389/fpls.2021.636663

MOREIRA-PINTO, C.E.; Ramos Coelho, R.; Borges Leite, A.G.; Amaral Silveira, D.; Aguiar Souza, D.; Biaggioni Lopes, R.; Macedo, L.L.P.; Mattar Silva, M.C.; Ribeiro, T.P.; Morgante, C.V.; Antonino, J.D.; Grossi-de-Sa, M.F. (2021). Increasing susceptibility to through-induced knockdown: a perspective to combine biocontrol and biotechnology. Pest Management Science, v. 77, p. ps.6430. https://doi.org/10.1002/ps.6430

BASSO, M.F.; Costa, J.A.; Ribeiro, T.P.; Arraes, F.B.M.; Lourenço-Tessutti, I.T.; Macedo, A.F.; Neves, M.R.; Nardeli, S.M.; Arge, L.W.; Perez, C.E.A.; Silva, P.L.R; De Macedo, L.L.P.; Lisei-de-Sa, M.E.; Amorim, R.M.A.; Pinto, E.R.C.; Silva, M.C.M.; Morgante, C.V.; Floh, E.I.S.; Alves-Ferreira, M.; Grossi-de-Sa, M.F. (2021). Overexpression of the CaHB12 transcription factor in cotton (Gossypium hirsutum) improves drought tolerance. Plant Physiology and Biochemistry, v. 165, p. 80-93. https://doi.org/10.1016/j.plaphy.2021.05.009

PAES DE MELO, B.; Lourenço-Tessutti, I.T.; Fraga, O.T.; Pinheiro, L.B.; de Jesus Lins, C.B.; Morgante, C.V.; Engler, J.A.; Reis, P.A.B.; Grossi-De-Sá, M.F.; Fontes, E.P.B. (2021). Contrasting roles of GmNAC065 and GmNAC085 in natural senescence, plant development, multiple stresses and cell death responses. Scientific Reports, v. 11, p. 11178. https://doi.org/10.1038/s41598-021-90767-6

MOTA, A.P.Z.; Brasileiro, A.C.M.; Vidigal, B.; Oliveira, T.N.; da Cunha Quintana Martins, A.; Saraiva, M.A.P.; de Araújo, A.C.G.; Togawa, R.C.; Grossi-de-Sá, M.F.; Guimaraes, P.M. (2021). Defining the combined stress response in wild Arachis. Scientific Reports, v. 11, p. 11097. https://doi.org/10.1038/s41598-021-90607-7

RIBEIRO, T.P.; Lourenço-Tessutti, I.T.; De Melo, B.P.; Morgante, C.V.; Filho, A.S.; Lins, C.B.J.; Ferreira, G.F.; Mello, G.N.; Macedo, L.L.P.; Lucena, W.A.; Silva, M.C.M.; Oliveira-Neto, O.B.; Grossi-de-Sa, M.F. (2021). Improved cotton transformation protocol mediated by Agrobacterium and biolistic combined-methods. Planta, v. 254, p. 20. https://doi.org/10.1007/s00425-021-03666-5

ARAUJO SOUSA, B.; Nascimento Silva, O.; Farias Porto, W.; Lima Rocha, T.; Paulino Silva, L.; Ferreira Leal, A.P.; Buccini, D.F.; Oluwagbamigbe Fajemiroye, J.; de Araujo Caldas, R.; Franco, O.L.; Grossi-De-Sá, M.F.; de La Fuente Nunez, C.; Moreno, S.E. (2021). Identification of the active principle conferring anti inflammatory and antinociceptive properties in bamboo plant. Molecules, v. 26, p. 3054. https://doi.org/10.3390/molecules26103054

GODINHO MENDES, R.A.; Basso, M.F.; Fernandes de Araújo, J.; Paes De Melo, B.; Lima, R.N.; Ribeiro, T.P.; da Silva Mattos, V.; Saliba Albuquerque, E.V.; Grossi-De-Sa, M.; Dessaune Tameirao, S.N.; da Rocha Fragoso, R.; Mattar da Silva, M.C.; Vignols, F.; Fernandez, D.; Grossi-De-Sa, M.F. (2021). Minc00344 and Mj-NULG1a effectors interact with GmHub10 protein to promote the soybean parasitism by Meloidogyne incognita and M. javanica. Experimental Parasitology, v. 229, p. 108153. https://doi.org/10.1016/j.exppara.2021.108153

MOREIRA-PINTO, C.E.; Coelho, R.R.; Leite, A.G.B.; Silveira, D.A.; Souza, D.A.; Lopes, R.B.; Macedo, L.L.P.; Silva, M.C.M.; Ribeiro, T.P.; Antonino, J.D.; Grossi-de-Sa, M.F. (2021). Increasing Anthonomus grandis susceptibility to Metarhizium anisopliae through RNAi-induced AgraRelish knockdown: a perspective to combine biocontrol and biotechnology. Pest Management Science, v. 77, p. 4054-4063. https://doi.org/10.1002/ps.6430

LISEI-DE-SÁ, M.E.; Rodrigues-Silva, P.L.; Morgante, C.V.; de Melo, B.P.; Lourenço-Tessutti, I.T.; Arraes, F.B.M.; Sousa, J.P.A.; Galbieri, R.; Amorim, R.M.S.; de Lins, C.B.J.; Macedo, L.L.P.; Moreira, V.J.; Ferreira, G.F.; Ribeiro, T.P.; Fragoso, R.R.; Silva, M.C.M.; de Almeida-Engler, J.; Grossi-de-Sa, M.F. (2021). Pyramiding dsRNAs increases phytonematode tolerance in cotton plants. Planta, v. 254, p. 121. https://doi.org/10.1007/s00425-021-03776-0

PAES DE MELO, B.; Moura, S.M.; Morgante, C.V.; Pinheiro, D.H.; Alves, N.S.F.; Rodrigues-Silva, P.L.; Lourenço-Tessutti, I.T.; Andrade, R.V.; Fragoso, R.R.; Grossi-de-Sa, M.F. (2021). Regulated promoters applied to plant engineering: an insight over promising soybean promoters under biotic stress and their cis-elements. Biotechnology Research and Innovation, v. 5, p. e2021005. http://dx.doi.org/10.4322/biori.202105

ARRAES, F.B.M.; Martins-de-Sa, D.; Noriega Vasquez, D.D.; Melo, B.P.; Faheem, M.; de Macedo, L.L.P.; Morgante, C.V.; Barbosa, J.A.R.G.; Togawa, R.O.; Moreira, V.J.P.; Danchin, E.G.J.; Grossi-de-Sa, M.F. (2021). Dissecting protein domain variability in the core RNA interference machinery of five insect orders. RNA Biology, v. 18, p. 1653-1681. https://doi.org/10.1080/15476286.2020.1861816

 

2020

BASSO, M.F.; Arraes, F.B.M.; Grossi-de-Sa, M.; Vaz-Moreira, V.J.; Alves-Ferreira, M.; Grossi-de-Sa, M.F. (2020). Insights into genetic and molecular elements for transgenic crop development. Frontiers in Plant Science, v. 11, p. 509. https://doi.org/10.3389/fpls.2020.00509

BASSO, M.F.; Lourenço-Tessutti, I.T.; Busanello, C.; Pinto, C.E.M.; Oliveira-Freitas, E.; Ribeiro, T.P.; Almeida-Engler, J.; Oliveira, A.C.; Morgante, C.V.; Alves-Ferreira, M.; Grossi-de-Sa, M.F. (2020). Insights obtained using different modules of the cotton uceA1.7 promoter. Planta, v. 251, p. 56. https://doi.org/10.1007/s00425-020-03348-8

BASSO, M.F.; Lourenço-Tessutti, I.T.; Mendes, R.A.G.; Pinto, C.E.M.; Bournaud, C.; Gillet, F.X.; Togawa, R.C.; Macedo, L.L.P.; Almeida-Engler, J.; Grossi-de-Sa, M.F. (2020). MiDaf16-like and MiSkn1-like gene families are reliable targets to develop biotechnological tools for the control and management of Meloidogyne incognita. Scientific Reports, v. 10, p. 6991. https://doi.org/10.1038/s41598-020-63968-8

BEVITORI, R.; Sircar, S.; Mello, R.N.; Togawa, R.C.; Cortes, M.V.C.B.; Oliveira, T.S.; Grossi-de-Sa, M.F.; Parekh, N. (2020). Identification of co-expression gene networks controlling rice blast disease during an incompatible reaction. Genetics Molecular Research, v. 19, p. gmr18579. https://doi.org/10.4238/gmr18579

CABRAL, D.N.; Banora, M.Y.; Antonino, J.D.; Rodiuc, N.; Vieira, P.; Coelho, R.R.; Chevalier, C.; Eekhout, T.; Engler G.; De-Veylder, L.; Grossi-de-Sa, M.F.; Almeida-Engler, J. (2020). The plant WEE1 kinase is involved in checkpoint control activation in nematode-induced galls. New Phytologist, v. 225(1), p. 430-447. https://doi.org/10.1111/nph.16185

CAMPOS, M.L.; Prado, G.S.; Santos, V.O.; Nascimento, L.C.; Dohms, S.M.; Cunha, N.B.; Ramada, M.H.S.; Grossi-de-Sa, M.F.; Dias, S.C. (2020). Mosses: versatile plants for biotechnological applications. Biotechnology Advances, v. 6, p. 107533. https://doi.org/10.1016/j.biotechadv.2020.107533

FIRMINO, A.A.P.; Pinheiro, D.H.; Pinto, C.E.M.; Antonino, J.D.; Macedo, L.L.P.; Martins-de-Sa, D.; Arraes, F.B.M.; Coelho, R.R.; Fonseca, F.C.A.; Silva, M.C.M.; Almeida-Engler, J.; Silva, M.S.; Lourenço-Tessutti, I.T.; Terra, W.R.; Grossi-de-Sa, M.F. (2020). RNAi-mediated suppression of Laccase2 impairs cuticle tanning and molting in the cotton boll weevil (Anthonomus grandis). Frontiers in Physiology, v. 11, p. 591569. https://doi.org/10.3389/fphys.2020.591569

GRYNBERG, P.; Togawa, R.C.; Freitas, L.D.; Antonino, J.D.; Rancurel, C.; Costa, M.M.C.; Grossi-de-Sa, M.F.; Miller, R.N.G.; Brasileiro, A.C.M.; Guimaraes, P.M.; Danchin, E.G.J. (2020). Comparative genomics reveals novel target genes towards specific control of plant-parasitic nematodes. Genes, v. 11, p. 1347. https://doi.org/10.3390/genes11111347

IBARRA, L.N.; Alves, A.E.O.A.; Antonino, J.D.; Prado, G.S.; Pinto, C.E.M.; Soccol, C.R.; Vasconcelos, E.A.R.; Grossi-de-Sa, M.F. (2020). Enzymatic activity of a recombinant β-1,4-endoglucanase from the cotton boll weevil (Anthonomus grandis) aiming second generation ethanol production. Scientific Reports, v. 10(1), p. 5367. https://doi.org/10.1038/s41598-019-56070-1

MOTA, A.P.Z.; Fernandez, D.; Arraes, F.B.M.; Petitot, A.S.; Paes-Melo, B.; Lisei-de-Sa, M.E.; Guimaraes, P.M.; Brasileiro, A.C.M.; Albuquerque, E.V.S.; Danchin, E.G.J.; Grossi-de-Sa, M.F. (2020). Evolutionarily conserved plant genes responsive to root-knot nematodes identified by comparative genomics. Molecular Genetics and Genomics, v. 295, p. 1063-1078. https://doi.org/10.1007/s00438-020-01677-7

MOURA, S.M.; Rossi, M.L.; Artico, S.; Grossi-de-Sa, M.F.; Martinelli, A.P.; Alves-Ferreira, M. (2020). Characterization of floral morphoanatomy and identification of marker genes preferentially expressed during specific stages of cotton flower development. Planta, v. 252(4), p. 71. https://doi.org/10.1007/s00425-020-03477-0

NORIEGA-VASQUEZ, D.D.; Arraes, F.B.M.; Antonino, J.D.; Macedo, L.L.P.; Fonseca, F.C.A.; Togawa, R.C.; Grynberg, P.; Silva, M.C.M.; Negrisoli, A.S.; Grossi-de-Sa, M.F. (2020). Transcriptome analysis and knockdown of the juvenile hormone esterase gene reveal abnormal feeding behavior in the sugarcane giant borer. Frontiers in Physiology, v. 11, p. 588450. https://doi.org/10.3389/fphys.2020.588450

NORIEGA-VASQUEZ, D.D.; Arraes, F.B.M.; Antonino, J.D.; Macedo, L.L.P.; Fonseca, F.C.A.; Togawa, R.C.; Grynberg, P.; Silva, M.C.M.; Negrisoli, A.S.; Morgante, C.V.; Grossi-de-Sa, M.F. (2020). Comparative gut transcriptome analysis of Diatraea saccharalis in response to the dietary source. PLoS One, v. 15(8), p. e0235575. https://doi.org/10.1371/journal.pone.0235575

PAES-MELO, B.; Lourenço-Tessutti, I.T.; Morgante, C.V.; Santos, N.C.; Pinheiro, L.B.; Jesus-Lins, C.B.; Silva, M.C.M.; Macedo, L.L.P.; Fontes, E.P.B.; Grossi-de-Sa, M.F. (2020). Soybean embryonic axis transformation: combining biolistic and Agrobacterium-mediated protocols to overcome typical complications of in vitro plant regeneration. Frontiers in Plant Science, v. 11, p. 1228. https://doi.org/10.3389/fpls.2020.01228

PAES-MELO, B.; Lourenço-Tessutti, I.T.; Paixao, J.F.R.; Noriega-Vasquez, D.D.; Silva, M.C.M.; Almeida-Engler, J.; Fontes, E.P.B.; Grossi-de-Sa, M.F. (2020). Transcriptional modulation of AREB-1 by CRISPRa improves plant physiological performance under severe water deficit. Scientific Reports, v. 10(1), p. 16231. https://doi.org/10.1038/s41598-020-72464-y

RIBEIRO, T.P.; Basso, M.F.; Carvalho, M.H.; Macedo, L.L.P.; Silva, D.M.L.S.; Lourenço-Tessutti, I.T.; Oliveira-Neto, O.B.; Romano, E.; Lucena, W.A.; Silva, M.C.M.; Tripode, B.M.D.; Abreu-Jardin, T.P.F.; Miranda, J.E.; Alves-Ferreira, M.; Morgante, C.V.; Grossi-de-Sa, M.F. (2020). Stability and tissue-specific Cry10Aa overexpression improves cotton resistance to the cotton boll weevil. Biotechnology Research & Innovation, v. 3, p. 15. https://doi.org/10.1016/j.biori.2019.12.003

2019

BASSO, A.M.M.; Castro, R.J.A.; Castro, T.B.; Guimaraes, H.I.; Polez, V.L.P.; Carbonero, E.R.; Pomin, V.H.; Hoffmann, C.; Grossi-de-Sa, M.F.; Tavares, A.H.; Bocca, A.L. (2019). Immunomodulatory activity of β-glucan-containing exopolysaccharides from Auricularia auricular in phagocytes and mice infected with Cryptococcus neoformans. Medical Mycology, v. 58(2), p. 227-239. https://doi.org/10.1093/mmy/myz042

BASSO, M.F.; Ferreira, P.C.G.; Kobayashi, A.K.; Harmon, F.G.; Nepomuceno, A.L.; Molinari, H.B.C.; Grossi-de-Sa, M.F. (2019). MicroRNAs and new biotechnological tools for its modulation and improving stress tolerance in plants. Plant Biotechnology Journal, v. 17(8), p. 1482-1500. https://doi.org/10.1111/pbi.13116

 

FIGUEIREDO, L.H.M.; Vasconcellos, A.G.; Prado, G.S.; Grossi-de-Sa, M.F. (2019). An overview of intellectual property within agricultural biotechnology in Brazil. Biotechnology Research & Innovation, v. 3(1), p. 69-79. https://doi.org/10.1016/j.biori.2019.04.003

FREITAS, E.O.; Paes-Melo, B.; Lourenço-Tessutti, I.T.; Arraes, F.B.M.; Amorim, R.M.S.; Lisei-de-Sa, M.E.; Costa, J.A.; Leite, A.G.B.; Faheem, M.; Ferreira, M.A.; Morgante, C.V.; Fontes, E.P.B.; Grossi-de-Sa, M.F. (2019). Identification and characterization of the GmRD26 soybean promoter in response to abiotic stresses: potential tool for biotechnological application. BMC Biotechnology, v. 19(1), p. 79. https://doi.org/10.1186/s12896-019-0561-3

GROSSI-DE-SA, M.; Petitot, A.S.; Xavier, D.A.; Lisei-de-Sa, M.E.; Mezzalira, I.; Beneventi, M.A.; Martins, N.F.; Baimey, H.K.; Albuquerque, E.V.S.; Grossi-de-Sa, M.F.; Fernandez, D. (2019). Rice susceptibility to root-knot nematodes is enhanced by the Meloidogyne incognita MSP18 effector gene. Planta, v. 250, p. 1215-1227. https://doi.org/10.1007/s00425-019-03205-3

HABIBI, P.; Henry, D.; Soccol, C.R.; Grossi-de-Sa, M.F. (2019). The potential of plant systems to break the HIV-TB link. Plant Biotechnology Journal, v. 17(10), p. 1868-1891. https://doi.org/10.1111/pbi.13110

MATTOS, V.S.; Mulet, K.; Cares, J.E.; Gomes, C.B.; Fernandez, D.; Grossi-de-Sa, M.F.; Carneiro, R.M.D.G.; Castagnone-Sereno, P. (2019). Development of diagnostic SCAR markers for Meloidogyne graminicola, M. oryzae, and M. salasi associated with irrigated rice fields in Americas. Plant Disease, v. 103, p. 83-88. https://doi.org/10.1094/PDIS-12-17-2015-RE

MOTA, A.P.Z.; Oliveira, T.N.; Vinson, C.C.; Williams, T.C.R.; Costa, M.M.C.; Araujo, A.C.G.; Danchin, E.G.J.; Grossi-de-Sa, M.F.; Guimaraes, P.M.; Brasileiro, A.C.M. (2019). Contrasting effects of wild Arachis dehydrin under abiotic and biotic stresses. Frontiers in Plant Science, v. 10, p. 497. https://doi.org/10.3389/fpls.2019.00497

NORIEGA-VASQUEZ, D.D.; Arias, P.L.; Barbosa, H.R.; Arraes, F.B.M.; Ossa, G.A.; Villegas, B.; Coelho, R.R.; Albuquerque, E.V.S.; Togawa, R.C.; Grynberg, P.; Wang, H.; Vélez, A.M.; Arboleda, J.W.; Grossi-de-Sa, M.F.; Silva, M.C.M.; Valencia-Jiménez, A. (2019). Transcriptome and gene expression analysis of three developmental stages of the coffee berry borer, Hypothenemus hampei. Scientific Reports, v. 9(1), p. 12804. https://doi.org/10.1038/s41598-019-49178-x

PAIXAO, J.F.R.; Gillet, F.X.; Ribeiro, T.P.; Bournaud, C.; Lourenço-Tessutti, I.T.; Noriega-Vasquez, D.D.; Paes-Melo, B.; Almeida-Engler, J.; Grossi-de-Sa, M.F. (2019). Improved drought stress tolerance in Arabidopsis by CRISPR/dCas9 fusion with a Histone AcetylTransferase. Scientific Reports, v. 9(1), p. 8080. https://doi.org/10.1038/s41598-019-44571-y

PRADO, G.S.; Bamogo, P.K.A.; Abreu, J.A.C.; Gillet, F.X.; Santos, V.O.; Silva, M.C.M.; Brizard, J.P.; Bemquerer, M.P.; Bangratz, M.; Brugidou, C.; Sérémé, D.; Grossi-de-Sa, M.F.; Lacombe, S. (2019). Nicotiana benthamiana is a suitable transient system for high-level expression of an active inhibitor of cotton boll weevil α-amylase. BMC Biotechnology, v. 19(1), p. 15. https://doi.org/10.1186/s12896-019-0507-9

IBARRA, L.N.; Alves, A.N.O.A.; Antonino, J.D.; Prado, G.S.; Pinto, C.E.M.; Soccol, C.R.; Vasconcelos, E.A.R.; Grossi-de-Sa, M.F. (2019). Enzymatic activity of a recombinant β-1,4-endoglucanase from the Cotton Boll Weevil (Anthonomus grandis) aiming second generation ethanol production. Scientific Reports, v. 9, p. 19580. https://doi.org/10.1038/s41598-019-56070-1

SANTOS, CRISTIANE; Nogueira, F.C.S.; Domont, G.B.; Fontes, W.; Prado, G.S.; Habibi, P.; Santos, V.O.; Oliveira-Neto, O.B.; Grossi-De-Sá, M.F.; Jorrín-Novo, J.V.; Franco, O.L.; Mehta, A. (2019). Proteomic analysis and functional validation of a Brassica oleracea Endochitinase involved in resistance to Xanthomonas campestris. Frontiers in Plant Science, v. 10, p. 414. https://doi.org/10.3389/fpls.2019.00414

2018

BOURNAUD, C.; Gillet, F.X.; Murad, A.M.; Bresso, E.; Albuquerque, E.V.S.; Grossi-de-Sa, M.F. (2018). Meloidogyne incognita PASSE-MURAILLE (MiPM) gene encodes a cell-penetrating protein that interacts with the CSN5 subunit of the COP9 signalosome. Frontiers in Plant Science, v. 9, p. 904. https://doi.org/10.3389/fpls.2018.00904

HABIBI, P.; Soccol, C.R.; Okeefe, B.R.; Krumpe, L.R.H.; Wilson, J.; Macedo, L.L.P.; Faheem, M.; Santos, V.O.; Prado, G.Z.; Botelho, M.A.; Lacombe, S.; Grossi-de-Sa, M.F. (2018). Gene-silencing suppressors for high-level production of the HIV-1 entry inhibitor griffithsin in Nicotiana benthamiana. Process Biochemistry, v. 70, p. 45-54. https://doi.org/10.1016/j.procbio.2018.04.006

NARDELI, S.M.; Artico, S.; Aoyagi, G.M.; Moura, S.M.; Franca-Silva, T.; Grossi-de-Sa, M.F.; Romanel, E.; Alves-Ferreira, M. (2018). Genome-wide analysis of the MADS-box gene family in polyploid cotton (Gossypium hirsutum) and in its diploid parental species (Gossypium arboreum and Gossypium raimondii). Plant Physiology and Biochemistry, v. 127, p. 169-184. https://doi.org/10.1016/j.plaphy.2018.03.019

SILVA, M.S.; Arraes, F.B.M.; Campos, M.A.; Grossi-de-Sa, M.; Fernandez, D.; Cândido, E.S.; Cardoso, M.H.; Franco, O.L.; Grossi-de-Sa, M.F. (2018). Review: potential biotechnological assets related to plant immunity modulation applicable in engineering disease-resistant crops. Plant Science, v. 270, p. 72-84. https://doi.org/10.1016/j.plantsci.2018.02.013

 

2017

ALBUQUERQUE, E.V.S.; Petitot, A.S.; Silva, J.P.; Grossi-de-Sa, M.F.; Fernandez, D. (2017). Early responses of coffee immunity-related genes to root-knot nematode infection. Physiological and Molecular Plant Pathology, v. 100, p. 142-150. https://doi.org/10.1016/j.pmpp.2017.09.001

ALMEIDA-GARCIA, R.; Macedo, L.L.P.; Cabral, D.N.; Gillet, F.X.; Pinto, C.E.M.; Faheem, M.; Basso, A.M.M.; Silva, M.C.M.; Grossi-de-Sa, M.F. (2017). Nucleases as a barrier to gene silencing in the cotton boll weevil, Anthonomus grandis. PLoS One, v. 12(12), p. e0189600. https://doi.org/10.1371/journal.pone.0189600

ANTONINO, J.D.; Pierre, O.; Coelho, R.R.; Grossi-de-Sa, M.F.; Engler, G.; Almeida-Engler, J. (2017). Application of nuclear volume measurements to comprehend the cell cycle in root-knot nematode-induced giant cells. Frontiers in Plant Science, v. 8, p. 961. https://doi.org/10.3389/fpls.2017.00961

GILLET, F.X.; Almeida-Garcia, R.; Macedo, L.L.P.; Albuquerque, E.V.S.; Silva, M.C.M.; Grossi-de-Sa, M.F. (2017). Investigating engineered ribonucleoprotein particles to improve oral RNAi delivery in crop insect pests. Frontiers in Physiology, v. 8, p. 1-14. https://doi.org/10.3389/fphys.2017.00256

GILLET, F.X.; Bournaud, C.; Antonino, J.D.; Grossi-de-Sa, M.F. (2017). Plant-parasitic nematodes: towards understanding molecular players in stress responses. Annals of Botany, v. 119, p. 260-775. https://doi.org/10.1093/aob/mcw260

HABIBI, P; Prado, G.S.; Pelegrini, P.B.; Hefferson, K.L.; Soccol, C.R.; Grossi-de-Sa, M.F. (2017). Optimization of inside and outside factors to improve recombinant protein yield in plant. Plant Cell Tissue and Organ Culture, v. 130, p. 449-467. https://doi.org/10.1007/s11240-017-1240-5

LISEI-DE-SA, M.E.; Arraes, F.B.M.; Brito, G.; Beneventi, M.A.; Lourenço-Tessutti, I.T.; Basso, A.M.M.; Amorim, R.M.S.; Silva, M.C.M.; Faheem, M., Oliveira, N.G.; Mizoi, J.; Yamaguchi-Shinozaki, K.; Grossi-de-Sa, M.F. (2017). AtDREB2A-CA influences root architecture and increases drought tolerance in transgenic cotton. Agricultural Sciences, v. 8(10), p. 1195-1225. https://doi.org/10.4236/as.2017.810087

MOURA, S.M.; Artico, S.; Lima, C.; Nardeli, S.M.; Berbel, A.; Oliveira-Neto, O.B.; Grossi-de-Sa, M.F.; Ferrándiz, C.; Madueño, F.; Alves-Ferreira, M. (2017). Functional characterization of AGAMOUS-subfamily members from cotton during reproductive development and in response to plant hormones. Plant Reproduction, v. 30(1), p. 19-39. https://doi.org/10.1007/s00497-017-0297-y

RAMOS, C.R.; Vieira, P.; Antonino, J.D.; Martin-Jimenez, C.; De-Veylder, L.; Cazareth, J.; Engler, G.; Grossi-de-Sa, M.F.; Almeida-Engler, J. (2017). Exploiting cell cycle inhibitor genes of the KRP family to control root-knot nematode induced feeding sites in plants. Plant, Cell and Environment, v. 40, p. 1174-1188. https://doi.org/10.1111/pce.12912

RIBEIRO, T.P.; Arraes, F.B.M.; Lourenço-Tessutti, I.T.; Silva, M.S.; Lisei-de-Sa, M.E.; Lucena, W.A.; Macedo, L.L.P.; Lima, J.N.; Amorim, R.M.S.; Artico, S.; Alves-Ferreira, M.; Silva, M.C.M.; Grossi-de-Sa, M.F. (2017). Transgenic cotton expressing Cry10Aa toxin confers high resistance to the cotton boll weevil. Plant Biotechnology Journal, v. 15(8), p. 997-1009. https://doi.org/10.1111/pbi.12694

 

2016

OLIVEIRA, R.S.; Oliveira-Neto, O.B.; Moura, H.F.; Macedo, L.L.P.; Arraes, F.B.M.; Lucena, W.A.; Lourenço-Tessutti, I.T.; Barbosa, A.A.D.; Silva, M.C.M.; Grossi-de-Sa, M.F. (2016). Transgenic cotton plants expressing Cry1Ia12 toxin confer resistance to fall armyworm (Spodoptera frugiperda) and cotton boll weevil (Anthonomus grandis). Frontiers in Plant Science, v. 7, p. 165. https://doi.org/10.3389/fpls.2016.00165

 

LACERDA, A.F.; Pelegrini, P.B.; Oliveira, D.M.; Vasconcelos, E.A.; Grossi-de-Sa, M.F. (2016). Anti-parasitic peptides from arthropods and their application in drug therapy. Frontiers in Microbiology, v. 7, p. 91. https://doi.org/10.3389/fmicb.2016.00091

COELHO, R.R.; Antonino, J.D.; Firmino, A.A.P.; Macedo, L.L.P.; Fonseca, F.C.A.; Terra, W.R.; Engler, G.; Almeida-Engler, J.; Silva, M.C.M.; Grossi-de-Sa, M.F. (2016). Vitellogenin knockdown strongly affects cotton boll weevil egg viability but not the number of eggs laid by females. Meta Gene, v. 9, p. 173-80. https://doi.org/10.1016/j.mgene.2016.06.005

GUIMARAES-DIAS, F.; Neves-Borges, A.C.; Conforte, A.J.; Giovanella-Kampmann, L.; Ferreira, A.V.J.; Amorim, R.M.S.; Beneventi, M.A.; Lisei-de-Sa, M.E.; Mesquita, R.O.; Rodrigues, F.A.; Nepomuceno, A.L.; Romano, E.; Loureiro, M.E.; Grossi-de-Sa, M.F.; Alves-Ferreira, M. (2016). Differential impact of acclimation and acute water deprivation in the expression of key transcription factors in soybean roots. Plant Molecular Biology Reporter, v. 34, p. 1167-1180. https://doi.org/10.1007/s11105-016-0993-z

 

VILLETH, G.R.; Carmo, L.S.; Silva, L.P.; Santos, M.F.; Oliveira-Neto, O.B.; Grossi-de-Sa, M.F.; Ribeiro, I.S.; Dessaune, S.N.; Fragoso, R.R.; Franco, O.L.; Mehta, A. (2016). Identification of proteins in susceptible and resistant Brassica oleracea responsive to Xanthomonas campestris pv. campestris infection. Journal Proteomics, v. 143, p. 278-285. https://doi.org/10.1016/j.jprot.2016.01.014